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Gian Luigi Gessa Selected Research

GABA-B Receptors

2/2013Reduction of alcohol intake by the positive allosteric modulator of the GABA(B) receptor, rac-BHFF, in alcohol-preferring rats.
10/2007Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice.
8/2006Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) in different rat lines.
11/2005Reducing effect of the positive allosteric modulators of the GABA(B) receptor, CGP7930 and GS39783, on alcohol intake in alcohol-preferring rats.
1/2004Baclofen reverses the reduction in prepulse inhibition of the acoustic startle response induced by dizocilpine, but not by apomorphine.
1/2004Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics.
6/2002Proconvulsive effect of the GABA(B) receptor antagonist, SCH 50911, in rats undergoing ethanol withdrawal syndrome.

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Gian Luigi Gessa Research Topics

Disease

14Alcoholism (Alcohol Abuse)
01/2021 - 11/2002
5Body Weight (Weight, Body)
10/2019 - 09/2005
5Obesity
06/2013 - 09/2005
5Substance-Related Disorders (Drug Abuse)
01/2013 - 09/2002
4Psychotic Disorders (Schizoaffective Disorder)
10/2007 - 01/2004
2Pain (Aches)
10/2019 - 03/2012
2Hyperphagia (Overeating)
01/2018 - 03/2013
2Cocaine-Related Disorders (Cocaine Addiction)
01/2018 - 02/2012
2Overweight
06/2013 - 01/2006
2Substance Withdrawal Syndrome (Withdrawal Symptoms)
01/2013 - 01/2007
2Cognitive Dysfunction
03/2012 - 01/2005
2Schizophrenia (Dementia Praecox)
10/2007 - 11/2004
2Seizures (Absence Seizure)
08/2006 - 06/2002
2Hyperprolactinemia
07/2002 - 06/2002
1Cancer Pain
10/2019
1Chronic Pain
10/2019
1Mental Disorders (Mental Disorder)
10/2019
1Acute Pain
10/2019
1Binge-Eating Disorder (Binge Eating Disorder)
01/2015
1Bulimia (Binge Eating)
01/2015
1Cachexia
05/2014
1Hypothermia
05/2014
1Neoplasms (Cancer)
05/2014
1Hyperalgesia
05/2014
1Metabolic Syndrome (Dysmetabolic Syndrome X)
06/2013
1Epilepsy (Aura)
03/2012
1Anxiety Disorders (Anxiety Disorder)
03/2012
1Sleep Deprivation
11/2008
1Ataxia (Dyssynergia)
02/2008
1Cushing Syndrome
01/2007
1Ischemia
10/2006
1Multiple Endocrine Neoplasia Type 2a (MEN 2)
03/2006
1Tremor (Tremors)
03/2006
1Binge Drinking
01/2005
1Pathologic Processes
04/2004
1Alcohol Withdrawal Delirium (Delirium Tremens)
01/2004
1Sleep Initiation and Maintenance Disorders (Insomnia)
05/2003
1Memory Disorders (Memory Loss)
04/2003
1Genetic Predisposition to Disease (Genetic Predisposition)
02/2003

Drug/Important Bio-Agent (IBA)

8BaclofenFDA LinkGeneric
01/2018 - 06/2002
7GABA-B ReceptorsIBA
02/2013 - 06/2002
4Dopamine (Intropin)FDA LinkGeneric
02/2012 - 06/2002
4CannabinoidsIBA
08/2007 - 01/2005
4EndocannabinoidsIBA
10/2006 - 11/2004
3gamma-Aminobutyric Acid (GABA)IBA
02/2013 - 02/2003
3Pharmaceutical PreparationsIBA
01/2013 - 09/2002
3Antipsychotic Agents (Antipsychotics)IBA
11/2008 - 06/2005
3(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acidIBA
02/2008 - 06/2002
3RimonabantIBA
08/2007 - 09/2005
3CB1 Cannabinoid Receptor (CB1 Receptor)IBA
08/2007 - 01/2006
3Ethanol (Ethyl Alcohol)IBA
01/2007 - 06/2002
2Disulfiram (Antabuse)FDA Link
01/2015 - 02/2012
2GABA-B Receptor AgonistsIBA
03/2012 - 06/2002
2AcidsIBA
02/2008 - 06/2002
2GABA-B Receptor AntagonistsIBA
02/2008 - 06/2002
2Diazepam (Valium)FDA LinkGeneric
01/2007 - 03/2006
2Amisulpride (Solian)IBA
07/2002 - 06/2002
1Opioid Analgesics (Opioids)IBA
10/2019
1Appetite Depressants (Anorectics)IBA
01/2018
1Dopamine Agonists (Dopamine Agonist)IBA
01/2018
1saikosaponin DIBA
01/2018
1Cisplatin (Platino)FDA LinkGeneric
05/2014
1LigandsIBA
02/2013
1Psychotropic Drugs (Psychoactive Drugs)IBA
01/2013
1Mixed Function Oxygenases (Monooxygenases)IBA
02/2012
1Norepinephrine (Noradrenaline)FDA LinkGeneric
02/2012
1CarbohydratesIBA
09/2011
1LipidsIBA
09/2011
1Starch (Cornstarch)IBA
10/2009
1alpha-AmylasesIBA
10/2009
14-hydroxybutyric acidIBA
02/2008
1CGP 35348IBA
02/2008
1ProdrugsIBA
02/2008
14-Butyrolactone (gamma Butyrolactone)IBA
02/2008
1Butyric Acid (Butanoic Acid)IBA
10/2007
1Sodium Oxybate (gamma Hydroxybutyrate)FDA Link
01/2007
1Hydrocortisone (Cortisol)FDA LinkGeneric
01/2007
1glyceryl 2-arachidonate (2-arachidonoylglycerol)IBA
10/2006
1Opioid Receptors (Opioid Receptor)IBA
06/2005
1Narcotic Antagonists (Opioid Antagonists)IBA
06/2005
1Drug CombinationsIBA
01/2005
1surinabantIBA
01/2005
1Cannabinoid Receptors (Cannabinoid Receptor)IBA
04/2004
1Hypnotics and Sedatives (Sedatives)IBA
01/2004
1Glutamic Acid (Glutamate)FDA Link
04/2003
1Cannabinoid Receptor AgonistsIBA
04/2003
1GABA-A Receptors (GABA(A) Receptor)IBA
02/2003
1carmoxiroleIBA
06/2002
1Bromocriptine (Parlodel)FDA LinkGeneric
06/2002

Therapy/Procedure

4Drug Therapy (Chemotherapy)
01/2021 - 01/2005
3Therapeutics
03/2013 - 01/2004
2Self Administration (Administration, Self)
06/2013 - 05/2006
1Patient-Controlled Analgesia (Analgesia, Patient Controlled)
10/2019
1Hypnosis (Mesmerism)
02/2008
1Induced Hypothermia
02/2008
1Traditional Medicine (Folk Remedies)
05/2003